Peptidic nanoparticles: for cancer diagnosis and therapy |
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Authors: | Email author" target="_blank">A?GraffEmail author D?Tropel SK?Raman G?Machaidze U?Aebi Email author" target="_blank">P?BurkhardEmail author |
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Institution: | (1) I.E. Muller Institute for Structural Biology, Biozentrum, University of Basel, Klingelbergtrasse 70, CH-4056 Basel, Switzerland;(2) The Institute of Materials Science, University of Connecticut, 97 North Eagleville Road, 06269-3136 Storrs, CT, USA |
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Abstract: | A challenging topic in cancer research is to create drug delivery system that can bring in a specific and noncytotoxic manner
a therapeutic compound. Usually, tumor targeting requires very specific compounds. Currently, peptide analogues like somatostatin,
neurotensin, or bombesin are used to target G-coupled receptors, which are overexpressed on tumor cells. However, many of
those analogues are rapidly degraded in the plasma and are cytotoxic 1–2]. Due to the limited efficiency and high toxicity
of conventional chemotherapy different strategies have been developed for non-cytotoxic cancer treatment and cancer localization
3–5].
The recent development in bio-nanotechnology offers new avenues for cancer therapy. A lot of studies have been devoted to
nanoparticulate delivery systems (10–100nm) like lipid or polymer particles 6–8]. Due to the nanometer sized of such cargos,
the transportation of therapeutic compounds in the blood stream is increased in terms of time circulation. But their surface
functionalization to improve drug-targeting properties is usually complicated and rather uneffective.
We have recently designed a novel type of functional nanoparticles with regular icosahedral symmetry, mimicking small, rigid
viral capsids (Fig. 1 (A)) and a diameter of about 17 nm (Fig. 1 (C)) which self-assemble from single polypeptide chains (Fig.
1 (B)). |
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