Increased plasma and tissue levels of vitamin E in the spontaneously diabetic BB rat |
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| Authors: | W A Behrens F W Scott R Madère K D Trick |
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| Affiliation: | Bureau of Nutritional Sciences, Food Directorate, Health Protection Branch, Ottawa, Ontario, Canada K1A OL2 |
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| Abstract: | Increased plasma and tissue levels of vitamin E were found in spontaneously diabetic BB rats (D) as well as asymptomatic/diabetes-prone BB rats (AD) in comparison to levels in non-diabetic control rats (ND). Treatment of D rats with insulin for 30 days returned plasma and tissue values of vitamin E to control levels. The changes reported here could not be explained solely on the basis of variations in total lipid content of plasma. These data suggest the metabolism of vitamin E is altered in asymptomatic and spontaneously diabetic BB rats and this alteration returns to control values following insulin treatment. Furthermore, it might be speculated that these data indicate a relationship between vitamin E and insulin. |
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| Keywords: | To whom correspondence and requests for reprints should be addressed |
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