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A medium-density genetic linkage map of the bovine genome |
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| Authors: | W. Barendse D. Vaiman S. J. Kemp Y. Sugimoto S. M. Armitage J. L. Williams H. S. Sun A. Eggen M. Agaba S. A. Aleyasin M. Band M. D. Bishop J. Buitkamp K. Byrne F. Collins L. Cooper W. Coppettiers B. Denys R. D. Drinkwater K. Easterday C. Elduque S. Ennis G. Erhardt L. Ferretti N. Flavin Q. Gao M. Georges R. Gurung B. Harlizius G. Hawkins J. Hetzel T. Hirano D. Hulme C. Jorgensen M. Kessler B. W. Kirkpatrick B. Konfortov S. Kostia C. Kuhn J. A. Lenstra H. Leveziel H. A. Lewin B. Leyhe L. Lil I. Martin Burriel R. A. McGraw J. R. Miller D. E. Moody S. S. Moore S. Nakane I. J. Nijman I. Olsaker D. Pomp A. Rando M. Ron A. Shalom A. J. Teale U. Thieven B. G. D. Urquhart D. -I. Vage A. Van de Weghe S. Varvio R. Velmala J. Vilkki R. Weikard C. Woodside J. E. Womack M. Zanotti P. Zaragoza |
| Affiliation: | 1. CSIRO Tropical Animal Production, University of Queensland, Level 3 Gehrmann Labs, Research Road, 4072, St. Lucia, Australia 2. Laboratoire de Genetique biochimique et de Cytogenetique, INRA-CRJ, F78352, Jouy en Josas, France 3. ILRI, PO Box 30709, Nairobi, Kenya 4. Shirakawa Institute of Animal Genetics, Odakura, Nishigo, Nishishirakawa, 961, Fukushima, Japan 5. BBSRC Roslin Instite, EH25 9PS, Roslin, Midlothian, Scotland 6. Department of Meat and Animal Science, University of Wisconsin-Madison, 53706, Madison, WI, USA 7. Agricultural Researh Organization, PO Box 6, 50-250, Bet Dagan, Israel 8. American Breeders Service, PO BOX 459, 53532, DeForest, WI, USA 9. Rhur Universitaet Bochum, Molekulare Humangenetik, Gbd. MA5, D-44780, Bochum, Germany 10. Faculty of Veterinary Medicine, University of Liege, Boulevard de Colonster 20, B-4000, Sart Tilman, Liege 1, Belgium 11. Department of Dairy Science, University of Wisconsin-Madison, 53706, Madison, WI, USA 12. Laboratorio de Genetica Bioquimica y Grupos Sanguineos, Facultad de Veterinaria, Zaragoza, Spain 13. Biotechnology Centre, University College Dublin, Belfield, Dublin 4, Ireland 14. Jnstitut fur Tierzucht und Haustiergenetik, Justut-Liebig-Universitaet Giessen, Ludwigstrasse, 21B, D-35390, Giessen, Germany 15. IDVGA-CNR, via Abbiategrasso 207, 1-27100, Pavia, Italy 16. Department of Veterinary Pathobiology, Texas A&M University, College Station, TX77843-4463, USA 17. Institut fuer Tierzucht und Vererbungsforschung, Tierazliche Hochschule, Hannover 71, D-30559, Germany 18. Ian Clunies Ross Laboratories, CSIRO Animal Health, Delivery Centre, Locked Bag 1, NSW 2148, Blacktown, Australia 19. Division of Animal Science and Animal Health, The Royal Veterinary and Agricultural University, Bulowsvej 13, 1870, Frederiksberg C, Denmark 20. Department of Immunology, Institute of Animal Physiology and Genetics Research, Cambridge Research Station, CB2 4AT, Babraham, Cambridge, UK 21. Department of Biosciences, Division of Genetics, University of Helsinki, Viikinkaari 5, PO Box 56, 00014, Finland 22. Forschunginstitut fuer die Biologie, Landwirtschafticher Nutztiere, 18196, Dummerstorf, Germany 23. Department of Bacteriology, Faculty of Veterinary Medicine, Institute for Infectious Diseases and Immunology, Yalelaan 1, 3508, Utrecht, CL, The Netherlands 24. Department of Animal Sciences, University of Illinois, 61801, Urbana, IL, USA 25. Department of Physiology and Pharmacology, University of Georgia, 30602-7389, Athens, GA, USA 26. Department of Animal Science, University of Nebraska Lincoln, 68583-0908, Lincoln, NE, USA 27. National Livestock Breeding Centre, Japan 28. Department of Morphology, Genetics and Aquatic Biology, Norwegian College of Veterinary Medicine, PO Box 8146 Dep., N-0033, Oslo, Norway 29. Dipartimento di Scienze delle Produzione Animali, Via N. Sauro 85, 85100, Potenza, Italy 30. Department of Genetics, Hebrew University of Jerusalem, 91094, Jerusalem, Israel 31. Department of Animal Science, Agricultural University of Norway, PO Box 5025, N-1432, As, Norway 32. Departmentof Animal Genetics and Breeding, Rijks Universiteit Ghent, Heidestraat 19, B-9820, Merelbeke, Belgium 33. Animal Breeding, Agricultural Research Centre, SF-31600, Jokioinen, Finland 34. Instituto Zootecnica, Facolta di Medicina Veterinaria, Universita degli Stidi di Milano, Via Trentacoste 2, 1-20134, Milano, Italy |
| Abstract: | A cattle genetic linkage map was constructed which covers more than 95 percent of the bovine genome at medium density. Seven hundred and forty six DNA polymorphisms were genotyped in cattle families which comprise 347 individuals in full sibling pedigrees. Seven hundred and three of the loci are linked to at least one other locus. All linkage groups are assigned to chromosomes, and all are orientated with regards to the centromere. There is little overall difference in the lengths of the bull and cow linkage maps although there are individual differences between maps of chromosomes. One hundred and sixty polymorphisms are in or near genes, and the resultant genome-wide comparative analyses indicate that while there is greater conservation of synteny between cattle and humans compared with mice, the conservation of gene order between cattle and humans is much less than would be expected from the conservation of synteny. This map provides a basis for high-resolution mapping of the bovine genome with physical resources such as Yeast and Bacterial Artificial Chromosomes as well as providing the underpinning for the interpolation of information from the Human Genome Project. Received: 15 August 1996 / Accepted: 15 September 1996 |
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