Alteration of secretin-stimulated cardiac adenylate cyclase activity in rats with portacaval shunt |
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| Authors: | S De Fontaine P Robberecht P De Neef J Christophe |
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| Affiliation: | 1. ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, Zhejiang 311215, PR China;2. College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, PR China;1. Key Laboratory of Solid Waste Treatment and Resource Recycle Ministry of Education, Southwest University of Science and Technology, Mianyang 621010, PR China;2. State Key Laboratory for Environment-friendly Energy Materials, Southwest University of Science and Technology, Mianyang 621010, PR China;3. School of Civil Engineering and Architecture, Southwest University of Science and Technology, Mianyang 621010, PR China;4. School of Traffic and Transportation Engineering, Changsha University of Science and Technology, Changsha 410114, PR China;5. Mine Functional Backfill Technology Research Centre, Xi''an University of Science and Technology, Xi''an 710054, PR China |
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| Abstract: | Wistar rats were submitted to portacaval anastomosis (PCA). Control rats were sham-operated and pair-fed (SOPF). After 3 weeks, PCA led to the hypertrophy of right atrium (+50%), left atrium (+67%) and both ventricles (+26%). The response of adenylate cyclase activity to secretin was specifically and markedly decreased in membranes from atria (-51 to 59%) and ventricles (-68 to 69%). These data suggest a decrease in the number of functional secretin receptors in heart considering that: the half-maximal stimulatory secretin concentration was unchanged; glucagon stimulations were unaltered and D,L-isoproterenol stimulations were hardly affected; the Gpp(NH)p-, NaF-, and forskolin-stimulated adenylate cyclase activities were moderately decreased (in ventricles, by 14-28%) or unchanged (in atria). |
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