Evidence of selective interaction between adenosine deaminase and acid phosphatase polymorphisms in fetuses carried by diabetic women |
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| Authors: | Bottini E. Gerlini G. Lucarini N. Amante A. Gloria-Bottini F. |
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| Affiliation: | (1) School of Medicine, 2nd University of Rome, Via Orazio Raimondo, I-00173 Rome, Italy;(2) 1st University of Rome, School of Medicine, Institute of Child Health, Rome, Italy;(3) Laboratory of Genetics, University of Camerino, School of Science, Camerino, Italy |
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| Abstract: | Summary Possible selective interaction between genetic polymorphisms of acid phosphatase locus 1 (ACP1) and adenosine deaminase (ADA) has been investigated in a sample of 211 infants from diabetic women, and in 350 consecutive infants from normal women. Newborns from diabetic pregnancies carrying the ADA2 allele show a lower proportion of BA and CB phenotypes (heterozygotes for the main allele of ACP1 system), compared with both their mothers and normal infants. The observation suggests that, in a diabetic environment, intrauterine selection may act against double heterozygotes for the ACP1 and ADA systems. |
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