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Identifying disease-specific genes based on their topological significance in protein networks |
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| Authors: | Zoltán Dezs? Yuri Nikolsky Tatiana Nikolskaya Jeremy Miller David Cherba Craig Webb Andrej Bugrim |
| Affiliation: | (1) GeneGo Inc, Renaissance Drive, Saint Joseph, Michigan, 49085, USA;(2) Program of Translational Medicine, Van Andel Research Institute, Bostwick Avenue NE, Grand Rapids, MI 49503, USA;(3) Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina Str, Moscow, Russia |
| Abstract: | BackgroundThe identification of key target nodes within complex molecular networks remains a common objective in scientific research. The results of pathway analyses are usually sets of fairly complex networks or functional processes that are deemed relevant to the condition represented by the molecular profile. To be useful in a research or clinical laboratory, the results need to be translated to the level of testable hypotheses about individual genes and proteins within the condition of interest. |
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