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Analysis of skewed X-chromosome inactivation in females with rheumatoid arthritis and autoimmune thyroid diseases |
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| Authors: | Ghazi Chabchoub Elif Uz Abdellatif Maalej Chigdem A Mustafa Ahmed Rebai Mouna Mnif Zouheir Bahloul Nadir R Farid Tayfun Ozcelik Hammadi Ayadi |
| Institution: | 1. Laboratoire de Génétique Moléculaire Humaine, Faculté de Médecine de Sfax, Avenue Majida Boulila, Sfax, 3029, Tunisie 2. Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University, Ankara, 06800, Turkey 3. Unité de Bioinformatique, Centre de Biotechnologie de Sfax, Sfax, BP, 3018, Tunisie 4. Service d'Endocrinologie, Centre Hospitalo-universitaire Hédi Chaker de Sfax, Rue El-Ferdaous, Sfax, 3029, Tunisie 5. Service de Médecine Interne, Centre Hospitalo-universitaire Hédi Chaker de Sfax, Rue El-Ferdaous, Sfax, 3029, Tunisie 6. Osancor Biotech Inc, 31 Woodland Drive, Watford, Herts, WD17 3BY, UK 7. Institute for Materials Science and Nanotechnology (UNAM), Bilkent University, Ankara, 06800, Turkey |
| Abstract: | IntroductionThe majority of autoimmune diseases such as rheumatoid arthritis (RA) and autoimmune thyroid diseases (AITDs) are characterized by a striking female predominance superimposed on a predisposing genetic background. The role of extremely skewed X-chromosome inactivation (XCI) has been questioned in the pathogenesis of several autoimmune diseases. |
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