Intracellular free calcium concentration in lymphocytes of patients with muscular dystrophies |
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| Authors: | F Mechler M Molnár M Balázs J Matkó |
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| Institution: | Department of Neurology and Psychiatry, University Medical School of Debrecen, Hungary. |
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| Abstract: | Intracellular free calcium concentration ( Ca2+]i) of human peripheral blood lymphocytes was determined by fluorescence spectroscopic measurements with quin2 in patients with different types of muscular dystrophy and in controls. The Ca2+]i level in lymphocytes showed a significant increase in adult type (facioscapulohumeral and limb-girdle) muscular dystrophies, while it showed a decrease in Duchenne dystrophy as compared to the values of age- and sex-matched controls. The data obtained suggest an alteration in the effectiveness of the calcium pump in lymphocytes and may represent a sign of generalized membrane damage in these hereditary muscle diseases. |
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