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The ten grand challenges of synthetic life |
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| Authors: | Manuel Porcar Antoine Danchin Victor de Lorenzo Vitor A. dos Santos Natalio Krasnogor Steen Rasmussen Andr��s Moya |
| Affiliation: | 1. Cavanilles Institute of Biodiversity and Evolutive Biology, Universitat de Val??ncia, 46020, Valencia, Spain 2. CEA/Genoscope, AMAbiotics SAS, Evry, France 3. National Center of Biotechnology CSIC, Campus de Cantoblanco, 28049, Madrid, Spain 4. Division of Microbiology, HZI-Helmholtz-Zentrum f??r Infektionsforschung, Braunschweig, Germany 5. School of Computer Science, Jubilee Campus, University of Nottingham, Nottingham, NG81BB, UK 6. Center for Fundamental Living Technology, University of Southern Denmark, 5230, Odense, Denmark 7. Santa Fe Institute, Santa Fe, NM, 87501, USA 8. Centro Superior de Investigaci??n en Salud P??blica (CSISP), Unidad Mixta de Investigaci??n en Gen??mica y Salud, Valencia, Spain |
| Abstract: | The construction of artificial life is one of the main scientific challenges of the Synthetic Biology era. Advances in DNA synthesis and a better understanding of regulatory processes make the goal of constructing the first artificial cell a realistic possibility. This would be both a fundamental scientific milestone and a starting point of a vast range of applications, from biofuel production to drug design. However, several major issues might hamper the objective of achieving an artificial cell. From the bottom-up to the selection-based strategies, this work encompasses the ten grand challenges synthetic biologists will have to be aware of in order to cope with the task of creating life in the lab. |
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