Synthesis and in vitro study of antiviral and virucidal activity of novel 2-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetamide derivatives |
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Authors: | Wujec Monika Plech Tomasz Siwek Agata Rajtar Barbara Polz-Dacewiczb Ma?gorzata |
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Institution: | Department of Organic Chemistry, Medical University, Staszica 6, 20-081 Lublin, Poland. monika.wujec@am.lublin.pl |
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Abstract: | 2-(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetamide derivatives were synthesized and their structures were confirmed by 1H NMR, IR, and elemental analysis. Cytotoxicity of the compounds towards HEK-293 and GMK cells was evaluated. Moreover, the antiviral and virucidal activities of these compounds against human adenovirus type 5 and ECHO-9 virus were assessed. Some of the newly synthesized derivatives have the potential to reduce the viral replication of both tested viruses. |
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