Potentiometric, spectrophotometric and calorimetric study on iron(III) and copper(II) complexes with 1,2-dimethyl-3-hydroxy-4-pyridinone |
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Authors: | Nurchi Valeria M Crisponi Guido Pivetta Tiziana Donatoni Martina Remelli Maurizio |
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Affiliation: | Dipartimento di Scienze Chimiche, Università di Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato-Cagliari, Italy. nurchi@unica.it |
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Abstract: | The iron(III)-1,2-dimethyl-3-hydroxy-4-pyridinone (Deferiprone) system is carefully characterized by a combined potentiometric-spectrophotometric procedure at 25 and 37 degrees C at different ionic strengths, and by thermochemical and quantum-chemical studies. The main purpose of this work was to determine how the temperature dependence of both complex-formation and protonation constants can affect the pFe values on going from 25 degrees C (pFe is normally calculated using 25 degrees C stability constants) to the physiological temperature of 37 degrees C at which chelating agents are active in vivo. The copper(II)-Deferiprone system is also studied and the iron(III)-Deferiprone distribution diagrams in presence of variable copper(II) amounts are shown so as to explain possible side effects due to a competing metal ion during the chelating therapy of iron overload. |
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Keywords: | 1,2-Dimethyl-3-hydroxy-4-pyridinone Iron(III) and copper(II) complexes Potentiometry Calorimetry Quantum-chemical calculation |
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