Effect of local microapplication of serotonergic drugs on membrane currents of Paracentrotus lividus early embryos |
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Authors: | Yu. B. Shmukler E. Tosti F. Silvestre |
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Affiliation: | (1) Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 199991, Russia;(2) Stazione Zoologica “Anton Dohrn”, 80121 Villa, Comunale, Napoli, Italia |
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Abstract: | It was shown that local application of agonists of the 3rd type receptors 5-HTQ and quipazine into the interblastomere cleft of Paracentrotus lividus embryos evoked specific membrane currents. At the same time, ligands of 5-HT3-receptors specifically affected the cleavage patterns of half-embryos, i.e., imitated or avoided the interblastomere signal. In the view of the data obtained, we discuss a more precise concept of protosynapse, where the distribution of membrane serotonin receptors is restricted to the period of blastomere formation during cleavage and localized in the area of interblastomere contact. |
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Keywords: | serotonin receptors cell interactions cleavage-division sea urchins |
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