The projections of chemically identified nerve fibres in canine ileum |
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| Authors: | E E Daniel Dr J B Furness M Costa L Belbeck |
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| Institution: | (1) Department of Neurosciences, McMaster University, Hamilton, Ontario, Canada;(2) Department of Pathology, McMaster University, Hamilton, Ontario, Canada;(3) Centre for Neuroscience, School of Medicine, Flinders University, Bedford Park, SA, Australia;(4) Department of Anatomy & Histology, School of Medicine, Flinders University, 5042 Bedford Park, SA, Australia |
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| Abstract: | Summary The projections of nerve fibres with immunoreactivity for the peptides enkephalin (ENK), gastrin-releasing peptide (GRP), neuropeptide Y (NPY), somatostatin (SOM), substance P (SP) and vasoactive intestinal peptide (VIP) were studied in canine small intestine by analysing the consequences of lesions of intrinsic and extrinsic nerves. Of peptides present in fibres supplying myenteric ganglia, GRP, SOM and VIP were in anally directed nerve pathways, whereas ENK and NPY were in orally directed pathways. Pathways ran for up to about 30 mm. SP fibres ran for short distances in both directions in the myenteric plexus. The circular muscle was supplied with ENK, NPY, SP and VIP fibres arising from the myenteric ganglia, whereas most mucosal SP and VIP fibres were deduced to arise from submucous ganglia. There were projections of fibres reactive for ENK, GRP, SOM, SP and VIP from myenteric ganglia to submucous ganglia. Antibodies to tyrosine hydroxylase were used to locate noradrenaline nerve fibres supplying the intestine; these fibres all disappeared when extrinsic nerves running through the mesentery to the small intestine were cut. It is deduced that there is an ordered pattern of projections of peptide-containing fibres in the canine intestine. |
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| Keywords: | Enkephalin Gastrin releasing peptide Neuropeptide Y Somatostatin Substance P Vasoactive intestinal peptide Enteric nervous system Intestine small Dog |
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