Interaction of MIF-I or alpha-MSH with D-amphetamine or chlorpromazine on thermoregulation and motor activity of rats maintained at different ambient temperatures |
| |
Authors: | Shlomo Yehuda Abba J. Kastin |
| |
Affiliation: | 1. Veterans Administration Medical Center, New Orleans, LA 70146 USA;2. Tulane University School of Medicine, New Orleans, LA 70146 USA |
| |
Abstract: | Administration of several doses of MIF-I or alpha-MSH did not modify colonic temperature or the level of motor activity of rats in ambient temperatures of 4 degree or 20 degrees C. However, the thermoregulatory but not motor effects of the interaction between MIF-I or alpha-MSH with d-amphetamine were dependent upon ambient temperature. At 4 degree C, 1.0 mg/kg of both peptides enhanced the d-amphetamine-induced hypothermia, but at 20 degrees C both peptides blocked the hyperthermic effects of d-amphetamine. The hypothermic effect of chlorpromazine (CPZ) at 4 degree C and 20 degrees C was blocked by 1.0 mg/kg MIF-I but not by 1.0 mg/kg alpha-MSH. No linear dose response relationships between various doses of MIF-I or alpha-MSH and thermal responses were found. Administration of melanin or the use of hypophysectomized rats did not alter the significant interactions observed after peripheral injections. |
| |
Keywords: | Peptides Amphetamine Phenothiazines Thermoregulation Ambient temperature Locomotion Drug interaction |
本文献已被 ScienceDirect 等数据库收录! |