| 酵母细胞凋亡机制研究进展 |
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| 引用本文： | 吴静,闵柔,雷艳丽,邬敏辰,陈伟. 酵母细胞凋亡机制研究进展[J]. 生物加工过程, 2010, 8(6): 67-72. DOI: 10.3969/j.issn.1672-3678.2010.06.013 |
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| 作者姓名： | 吴静 闵柔 雷艳丽 邬敏辰 陈伟 |
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| 作者单位： | 1. 江南大学,医药学院,无锡,214122;江南大学,工业生物技术教育部重点实验室,无锡,214122
2. 江南大学,医药学院,无锡,214122 |
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| 基金项目： | 中央高校基本科研业务费专项资金资助项目，工业生物技术教育部重点实验室开放课题，江南大学大学生创新训练计划资助项目 |
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| 摘 要： | 凋亡是一种主动有序发生、受多基因严密控制的细胞逐渐死亡过程,对维持机体正常的生命活动发挥着重要作用,酵母因能发生细胞凋亡且凋亡机制与哺乳动物细胞相比具有高度保守性而成为研究细胞凋亡的重要模式生物。综述近年来酵母细胞凋亡的关键调节因子、启动机制和信号通路的研究进展,并展望其潜在应用前景。
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| 关 键 词： | 酵母 细胞凋亡 调节因子 启动机制 信号通路 |
Research progress of yeast cell apoptosis and its mechanism |
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| WU Jin,MIN Rou,LEI Yan-li,WU Min-chen,CHEN Wei. Research progress of yeast cell apoptosis and its mechanism[J]. Chinese Journal of Bioprocess Engineering, 2010, 8(6): 67-72. DOI: 10.3969/j.issn.1672-3678.2010.06.013 |
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| Authors: | WU Jin MIN Rou LEI Yan-li WU Min-chen CHEN Wei |
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| Affiliation: | 1.School of Medicine and Pharmaceutics,Jiangnan University,Wuxi 214122,China;2.Key Laboratory ofIndustrial Biotechnology of the Ministry of Education,Jiangnan University,Wuxi 214122,China) |
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| Abstract: | The apoptosis is an active and orderly cell death process,tightly controlled by multiple genes.It plays an important role on the body to maintain normal life activities.Yeast is the single cell eukaryote that can be induced to undergo apoptosis,the mechanism of apoptosis in cells from yeast to mammals is highly conserved,so the yeast has become an important research model organism.In this review,the yeast is used as the model organism,and the studies on the key regulator of yeast apoptosis,the activation mechanism and signal pathways are summarized.Finally,the perspective of the yeast apoptosis was also given for its potential application. |
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| Keywords: | yeast cell apoptosis regulatory factors activation mechanism signal pathways |
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