Toll/Interleukin-1 Receptor Domain Dimers as the Platform for Activation and Enhanced Inhibition of Toll-like Receptor Signaling |
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Authors: | Ota Fekonja Mojca Bencina Roman Jerala |
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Affiliation: | From the Laboratory of Biotechnology, National Institute of Chemistry, 1000 Ljubljana, Slovenia. |
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Abstract: | TIR (Toll/IL-1 receptor) domains mediate interactions between TLR (Toll-like) or IL-1 family receptors and signaling adapters. While homotypic TIR domain interactions mediate receptor activation they are also usurped by microbial TIR domain containing proteins for immunosuppression. Here we show the role of a dimerized TIR domain platform for the suppression as well as for the activation of MyD88 signaling pathway. Coiled-coil dimerization domain, present in many bacterial TCPs, potently augments suppression of TLR/IL-1R signaling. The addition of a strong coiled-coil dimerization domain conferred the superior inhibition against the wide spectrum of TLRs and prevented the constitutive activation by a dimeric TIR platform. We propose a molecular model of MyD88-mediated signaling based on the dimerization of TIR domains as the limiting step. |
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Keywords: | Immunosuppression Innate Immunity MyD88 Toll IL-1 Receptor (TIR) Domain Toll-like Receptors (TLR) Bacterial TCPs TcpB |
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