Intranasal PUVA phototherapy in nasal polyposis--a pilot study |
| |
Authors: | Koreck Andrea Bella Zsolt Kadocsa Edit Perenyi Adam Tiszlavicz Laszlo Nemeth Istvan Kiss Maria Olariu Tudor Rares Jori Jozsef Kemeny Lajos |
| |
Institution: | Department of Dermatology and Allergology, University of Szeged, Hungary. akoreck@yahoo.com |
| |
Abstract: | Nasal polyposis (NP) affects 4% of the general population, representing a major health problem. In spite of complex (surgical and medical) treatment, the relapse rate is high and it has a negative impact on the quality of life. Recently we found that intranasal photochemotherapy with ultraviolet A light (PUVA) is effective in allergic rhinitis. In the present study PUVA was administered for 6 weeks in 7 patients with NP. Nasal lavages were performed in all patients before and at the end of the treatment; from four patients a biopsy specimen was also collected. Eosinophils significantly decreased in patients with NP and slightly in a patient who had associated aspirin sensitivity. IL-5 and eosinophil cationic protein (ECP) levels showed a decreasing trend in patients with NP and an increasing trend in patients with associated aspirin sensitivity. Our results suggest that intranasal PUVA might represent a future therapeutic method in a subset of patients with NP. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|