H2O2-Induced Platelet Aggregation and Increase in Intracellular Ca2+ Concentration Are Blocked by Inhibitors of Intracellular Signaling |
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Authors: | E. N. Loiko A. B. Samal S. M. Shulyakovskaya |
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Affiliation: | (1) Department of Biophysics, Belarusian State University, pr. F. Skoriny 4, Minsk, 220050, Belarus;(2) National Academy of Sciences of Belarus, ul. Akad. Kuprevicha 5/2, Institute of Bioorganic Chemistry, Minsk, 220141, Belarus |
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Abstract: | Inhibitors of signaling enzymes such as guanosine-5-O-2-thiodiphosphate, aristolochic acid, aspirin, indomethacin, and trifluoperazine block H2O2-induced platelet aggregation and H2O2-induced increase in the intracellular concentration of Ca2+. These findings suggest that the effect of H2O2 on platelets is associated with activation of signal pathways responsible for increase in the concentration of intracellular Ca2+. On H2O2-induced platelet aggregation, the concentration of cAMP in the cytoplasm decreases and that of cGMP increases. |
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Keywords: | hydrogen peroxide platelets platelet aggregation intracellular Ca2+ cAMP cGMP inhibitors ADP arachidonic acid |
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