H2O2-Induced Platelet Aggregation and Increase in Intracellular Ca2+ Concentration Are Blocked by Inhibitors of Intracellular Signaling期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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H2O2-Induced Platelet Aggregation and Increase in Intracellular Ca2+ Concentration Are Blocked by Inhibitors of Intracellular Signaling

Authors:	E N Loiko A B Samal S M Shulyakovskaya

Institution:	(1) Department of Biophysics, Belarusian State University, pr. F. Skoriny 4, Minsk, 220050, Belarus;(2) National Academy of Sciences of Belarus, ul. Akad. Kuprevicha 5/2, Institute of Bioorganic Chemistry, Minsk, 220141, Belarus

Abstract:	Inhibitors of signaling enzymes such as guanosine-5-O-2-thiodiphosphate, aristolochic acid, aspirin, indomethacin, and trifluoperazine block H₂O₂-induced platelet aggregation and H₂O₂-induced increase in the intracellular concentration of Ca²⁺. These findings suggest that the effect of H₂O₂ on platelets is associated with activation of signal pathways responsible for increase in the concentration of intracellular Ca²⁺. On H₂O₂-induced platelet aggregation, the concentration of cAMP in the cytoplasm decreases and that of cGMP increases.

Keywords:	hydrogen peroxide platelets platelet aggregation intracellular Ca²⁺ cAMP cGMP inhibitors ADP arachidonic acid
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