Ergosterol levels in two l-methionine-enriched mutants of the methylotrophic yeast Candida boidinii ICCF26 |
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Authors: | Dorina Avram Rodica Stan |
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Affiliation: | Department of Genetic Engineering, Institute of Biology, Bucharest, Romania. |
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Abstract: | Two L-methionine-enriched mutants, SN-78 and SE-57, were isolated in a sulphur-deficient medium from the methylotrophic yeast Candida boidinii ICCF26. No significant differences were detected between the L-cysteine pools of the mutants and the wild-type. In mutant strain SE-57, S-adenosylmethionine and ergosterol levels were higher than in the wild-type strain, while in the other mutant, SN-78, the levels were lower. The evidence presented would suggest that, in both the mutants and the wild-type used in this study, S-adenosylmethionine was of key importance for the accumulation of L-methionine and ergosterol. |
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Keywords: | Candida boidinii Methylotrophic yeast l-Methionine-enriched mutant S-Adenosylmethionine Ergosterol |
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