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Efflux pumps and drug resistance in Gram-negative bacteria |
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| Authors: | Dzwokai Ma David N Cook John E Hearst Hiroshi Nikaido |
| Institution: | a D. Ma, D.N. Cook and J.E. Hearst are in Dept of Chemistry, University of California, Berkeley, CA 94720, USA b H. Nikaido is Dept of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA |
| Abstract: | The outer membrane of Gram-negative bacteria can only slow down the influx of lipophilic inhibitors, and so these bacteria need active efflux pumps of broad specificity to survive. Pumps such as the Escherichia coli Acr system and its homologs make Gram-negative bacteria resistant to dyes, detergents and antibiotics. |
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