Significant prolongation of disease-free period gained by oral polysaccharide K (PSK) administration after curative surgical operation of colorectal cancer |
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Authors: | Motomichi Torisu Yoshihiko Hayashi Toshiyuki Ishimitsu Takeshi Fujimura Kazunori Iwasaki Mitsuo Katano Hiroshi Yamamoto Yutaka Kimura Masaharu Takesue Motoharu Kondo Kikuo Nomoto |
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Affiliation: | (1) The First Department of Surgery, Kyushu University School of Medicine, 3-1-1 Maedashi, Higashi-ku, 812 Fukuoka, Japan;(2) Dept. of Surgery, Karatsu Red Cross Hospital, Saga, Japan;(3) Dept. of Surgery, Saga Medical College, Saga, Japan;(4) Kimura Hospital, Fukuoka, Japan;(5) The First Dept. of Med., Kyoto Prefectural Univ. Med., Kyoto, Japan;(6) Dept. of Immunol., Medical Institute of Bioregulation, Kyushu University School of Medicine, Fukuoka, Japan |
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Abstract: | Summary To examine the clinical efficacy and the mechanism of action of polysaccharide K (PSK), a proteinbound polysaccharide extracted from a Basidiomycetes fungus, a randomized double-blind trial was performed by administering PSK to 56 patients and a placebo to another group of 55 patients after surgical operations on their colorectal cancers. The rate of patients in remission (or disease-free) was significantly higher in the PSK group than in the placebo group; the difference between both groups was statistically significant atP <0.05 by the logrank test. The survival rate of patients was also significantly (P <0.05) higher in the PSK group than in the control group. The most significant laboratory finding was that polymorphonuclear leukocytes from PSK-treated patients showed remarkable enhancement in their activities, such as random and/or chemotactic locomotion, and phagocytic activity, when compared with those in the control group. In conclusion, PSK was useful as a maintenance therapy for patients after their curative surgical operations for colorectal cancer. The beneficial effects were probably due to the activation of leukocyte functions as one of the many biological-response-modifying (activities induced by PSK). |
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