Low-replicating viruses and strong anti-viral immune response associated with prolonged disease control in a superinfected HIV-1 LTNP elite controller |
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Authors: | Pernas María Casado Concepción Arcones Carolina Llano Anuska Sánchez-Merino Víctor Mothe Beatriz Vicario José L Grau Eulalia Ruiz Lidia Sánchez Jorge Telenti Amalio Yuste Eloísa Brander Christian Galíndez Cecilio López- |
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Institution: | Servicio de Virología Molecular, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain. |
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Abstract: | ObjectiveTo study the causes for the lack of clinical progression in a superinfected HIV-1 LTNP elite controller patient.Methodology and Principal FindingsWe studied host genetic, virological and immunological factors associated with viral control in a SI long term non progressor elite controller (LTNP-EC). The individual contained both viruses and maintained undetectable viral loads for >20 years and he did not express any of the described host genetic polymorphisms associated with viral control. None of four full-length gp160 recombinants derived from the LTNP-EC replicated in heterologous peripheral blood mononuclear cells. CTL responses after SI were maintained in two samples separated by 9 years and they were higher in breadth and magnitude than responses seen in most of 250 treatment naïve patients and also 25 controller subjects. The LTNP-EC showed a neutralization response, against 4 of the 6 viruses analyzed, superior to other ECs.ConclusionsThe study demonstrated that a strong and sustained cellular and humoral immune response and low replicating viruses are associated with viral control in the superinfected LTNP-EC. |
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