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Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1‐mediated autophagy regulation
Authors:Jun Ren  Li Zhu  Xihui Xu  Asli F. Ceylan  Wei Guo  Jian Yang  Yingmei Zhang
Affiliation:1. Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China;2. Center for Cardiovascular Research and Integrative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, USAEqual contribution.;3. Center for Cardiovascular Research and Integrative Medicine, School of Pharmacy, University of Wyoming, Laramie, WY, USA;4. Department of Animal Sciences, University of Wyoming, Laramie, WY, USA;5. Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China
Abstract:
Keywords:aging  Akt  autophagy  cardiac geometry  contractile function
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