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Purine metabolism in Trypanosoma brucei gambiense |
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| Authors: | Wallace R Fish JJoseph Marr Randolph L Berens |
| Institution: | Department of Medicine and Microbiology, St. Louis University School of Medicine, 3555 Vista, St. Louis, MO 63104 U.S.A. |
| Abstract: | The procyclic forms of Trypanosoma brucei gambiense do not incorporate glycine or serine into ribonucleotides. Although de novo purine synthesis does not occur, all purine bases and ribonucleotides are interconverted, indicating the presence of active salvage pathways. Guanine is actively deaminated to xanthine by guanase activity. Purine ribonucleosides are cleaved to their respective free bases. The order of salvage efficiency for purine bases and their respective ribonucleotides is: adenine > hypoxanthine > guanine > xanthine. |
| Keywords: | Purine metabolism Guanase Purine salvage pathway (Trypanosoma brucei gambiense) Mops AICA 5-aminoimidazole-4-carboximide AICAR 5-aminoimidazole-4-carboxamide ribosylphosphate |
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