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Reprogramming progeria fibroblasts re‐establishes a normal epigenetic landscape
Authors:Alton Etheridge  Hilmar Strickfaden  Zhigang Jin  Gareth Palidwor  Ji‐Hoon Cho  Kai Wang  Sarah Y Kwon  Carole Doré  Angela Raymond  Akitsu Hotta  James Ellis  Rita A Kandel  F Jeffrey Dilworth  Theodore J Perkins  Michael J Hendzel  David J Galas  William L Stanford
Institution:1. Pacific Northwest Diabetes Research Institute, Seattle, WA, USA;2. Cross Cancer Institute and the Department of Experimental Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada;3. The Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;4. Ottawa Bioinformatics Core Facility, The Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;5. Department of Chemical Engineering, University of Toronto, Toronto, Ontario, Canada;6. Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan;7. Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada;8. Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada;9. Pathology and Experimental Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada;10. Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada;11. Ottawa Institute of Systems Biology, Ottawa, Ontario, Canada;12. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
Abstract:
Keywords:aging  epigenetics  induced pluripotent stem cells  Lamin A  lamina  progeria  reprogramming
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