Regulation of protein kinases activity by quercetin in Ehrlich ascites tumor cells |
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Authors: | Yosef Graziani Reuben Chayoth Noga Karny Bianka Feldman Joseph Levy |
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Affiliation: | 1. Department of Biology, Ben Gurion University of the Negev, Beer Sheva Israel;2. Division of Endocrinology Health Science Faculty, Ben Gurion University of the Negev, Beer Sheva Israel |
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Abstract: | Cyclic AMP-independent protein kinase activities from Ehrlich ascites tumor cells, partially purified by DEAE-cellulose and phosphocellulose chromatography were inhibited by quercetin. The cyclic AMP in the tumor ascites cells and the cyclic AMP-dependent protein kinase activity from this tumor and from bovine and mouse tissues were unaffected by this drug. Since we reported that quercetin elevates cyclic AMP level in Ehrlich ascites tumor cells, this bioflavonoid may have a dual effect on the protein kinae activities in these cells, thus, increasing the cyclic AMP-dependent and decreasing the cyclic AMP-independent protein kinase activities. |
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Keywords: | Protein kinase regulation Quercetin Protein kinase inhibitor (Ehrlich ascites cell) Quercetin 3,3',4',5,7-pentahydroxy flavone |
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