Human papillomaviruses recruit cellular DNA repair and homologous recombination factors to viral replication centers |
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| Authors: | Gillespie Kenric A Mehta Kavi P Laimins Laimonis A Moody Cary A |
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| Institution: | Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. |
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| Abstract: | Human papillomaviruses (HPV) activate the ataxia telangiectasia mutated (ATM)-dependent DNA damage response to induce viral genome amplification upon epithelial differentiation. Our studies show that along with members of the ATM pathway, HPV proteins also localize factors involved in homologous DNA recombination to distinct nuclear foci that contain HPV genomes and cellular replication factors. These studies indicate that HPV activates the ATM pathway to recruit repair factors to viral genomes and allow for efficient replication. |
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