Analysis of structural and numerical chromosome abnormalities in sperm of normal men and carriers of constitutional chromosome aberrations. A review |
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| Authors: | Martina Guttenbach Wolfgang Engel M Schmid |
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| Institution: | Institut für Humangenetik, Biozentrum, Am Hubland, 97074 Würzburg, Germany Tel.: +49 931/888-4077; Fax: +49 931/888-4069, DE
Institut für Humangenetik, Go?lerstrasse 12d, D-37073 G?ttingen, Germany, DE
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| Abstract: | Sperm chromosome analysis offers the opportunity to gather information about the origin of chromosome aberrations in human
germ cells. Over the last 20 years more than 20 000 sperm chromosome complements from normal donors and almost 6000 spermatozoa
from men with constitutional chromosome aberrations (inversions, translocations) have been analyzed for structural and numerical
chromosome abnormalities, as well as for segregation of the constitutional chromosome aberrations after the sperm had penetrated
hamster oocytes. On the other hand, it took only 6 years to screen more than 3 million mature spermatozoa from healthy probands
for disomy rates of 20 autosomes (chromosomes 19 and 22 not evaluated) and the sex chromosomes, and for diploidy rates by
in situ hybridization techniques. In the present paper the results arising from both methods are compiled and compared.
Received: 29 January 1997 / Accepted: 5 March 1997 |
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