Immunoregulating activity of tumor-associated macrophages |
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Authors: | Graeme J Dougherty William H McBride |
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Institution: | (1) Lincoln's Inn Fields, Imperial Cancer Research Fund, WC2A 3PX London, England;(2) Department of Radiation Oncology and Jonsson Comprehensive Cancer Center, UCLA Center for Health Sciences, 90024 Los Angeles, CA, USA |
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Abstract: | Summary In this report, we examine the antigen nonspecific immunoregulating activity of macrophages isolated from the murine methylcholanthrene-induced fibrosarcoma FSA. These cells were shown to enhance the primary anti-CRBC PFC response of whole normal spleen cells in a dose-dependent fashion. This function was associated with a subpopulation of large Ia-negative macrophages and was mediated by a soluble macrophage-derived factor that appeared to act by stimulating the proliferation and/or differentiation of antigen-reactive T cells. The relationship of this factor to previously described monokines is discussed. |
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