Genotoxicity of 2,4,6-trichlorophenol in V79 Chinese hamster cells. |
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Authors: | K Jansson V Jansson |
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Affiliation: | Department of Cell Biology, University of Jyv?skyl?, Finland. |
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Abstract: | The genotoxicity of the rodent carcinogen 2,4,6-trichlorophenol (TCP) was studied without exogenous metabolic activation in V79 Chinese hamster cells. TCP did not induce mutation at the hprt locus to 6-thioguanine resistance or structural chromosome aberrations. However, it produced statistically significant, dose-related increases in hyperdiploidy and micronuclei. From these results it appears that TCP causes chromosome malsegregation as its major mode of genotoxic action. |
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