Enhanced resistance to Salmonella enterica serovar Typhimurium infection in mice after coumarin treatment |
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Authors: | Stefanova Tsvetanka Nikolova Nadja Michailova Anastasija Mitov Ivan Iancov Ianco Zlabinger Gerhard J Neychev Hristo |
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Institution: | Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, 26 Acad. G. Bonchev St., Sofia 1113, Bulgaria. |
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Abstract: | Coumarin and its derivatives are naturally occurring substances with multiple biological activities. Here we demonstrate that prophylactic peroral administration of coumarin or 7-hydroxycoumarin (7-OHC) enhances resistance to subsequent lethal Salmonella enterica Serovar Typhimurium infection in mice. 7-OHC decreased bacterial load in liver and spleen, and enhanced phagocytosis and bacterial killing by macrophages when applied in vitro and in vivo. 7-OHC treatment induced significant NO release in peritoneal macrophage cultures. The observed protective effect correlated with the induction of Th1-associated cytokines, such as IL-12, IFN-gamma, and TNF-alpha. These data demonstrate a clear immunomodulatory potential of coumarins which might have important therapeutic implications to enhance resistance to infection. |
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