Promiscuous origin of a chimeric sequence in the Escherichia coli O157:H7 genome |
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| Authors: | LeClerc J E Li B Payne W L Cebula T A |
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| Institution: | Molecular Biology Branch, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204, USA. |
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| Abstract: | A novel sequence of 2.9 kb in the intergenic region between the mutS and rpoS genes of Escherichia coli O157:H7 and closely related strains replaces a sequence of 6.1 kb in E. coli K-12 strains. At the same locus in Shigella dysenteriae type 1, a sequence identical to that in O157:H7 is bounded by the IS1 insertion sequence element. Extensive polymorphism in the mutS-rpoS chromosomal region is indicative of horizontal transfer events. |
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