Phosphoinositides specify polarity during epithelial organ development |
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| Authors: | Comer Frank I Parent Carole A |
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| Affiliation: | Laboratory of Cellular and Molecular Biology, Center for Cancer Research, NCI, NIH, 37 Convent Drive, Bldg. 37, Room 2066, Bethesda, MD 20892, USA. |
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| Abstract: | The molecular mechanisms that integrate cellular polarity with tissue architecture during epithelial morphogenesis are poorly understood. Using a three-dimensional model of epithelial morphogenesis, report that the phosphatase PTEN and phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] regulate the GTPase Cdc42 and the kinase aPKC to generate the apical plasma membrane domain and maintain apical-basolateral polarity. |
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