| HIV-1 gp120对鼠海马长时程增强效应的影响 |
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| 引用本文： | 董军,陆大祥,沈伟哉.HIV-1 gp120对鼠海马长时程增强效应的影响[J].病毒学报,2004,20(1):34-39. |
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| 作者姓名： | 董军 陆大祥 沈伟哉 |
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| 作者单位： | 暨南大学医学院,病理生理教研室,广东,广州,510632;暨南大学医学院,解剖教研室,广东,广州,510632 |
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| 摘 要： | 为了探讨人类免疫缺陷病毒Ⅰ型(HIV-1)的包膜糖蛋白gp120对鼠海马脑片CA1区的突触传递及可塑性的影响,应用离体脑片记录技术,记录大鼠海马CA1区的兴奋性突触后电位(excitatory postsynaptic potential,EPSP),研究了gp120对高频电刺激Schaffer侧支引起的鼠长时程增强效应(long-term potentiation,LTP)的影响.结果发现:gp120对大鼠海马CA1区LTP产生抑制作用,对其基础EPSP没有影响,而且这种抑制效应随着gp120浓度增大而增强,即具有剂量依赖性.PKA/PKC蛋白激酶抑制剂H7可以反转这种抑制效应.提示:gp120可能是通过抑制海马CA1区的LTP而参与艾滋病相关性痴呆(HIV-1 associated dementia,HAD)的形成.
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| 关 键 词： | HIV-1 gp120 LTP H7 海马脑片 |
| 文章编号： | 1000-8721(2004)01-0034-06 |
Effect of Long-term Potentiation by HIV-1 gp120 in Rat Hippocampus in vitro |
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| DONG Jun ,LU Da xiang ,SHEN Wei zai.Effect of Long-term Potentiation by HIV-1 gp120 in Rat Hippocampus in vitro[J].Chinese Journal of Virology,2004,20(1):34-39. |
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| Authors: | DONG Jun LU Da xiang SHEN Wei zai |
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| Institution: | DONG Jun 1,LU Da xiang 1,SHEN Wei zai 2 |
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| Abstract: | To understand the effect of gp120 on synaptic transmission and plasticity in the CA 1 region of rat hippocampal slices,we recorded the excitatory postsynaptic potentials (EPSPs) and investigated effect of long term potentiation by gp120 in rat hippocampus in vitro.The results showed that HIV 1 gp120 could inhibit the LTP of CA 1,but it could not inhibit the EPSP of basal.The greater the gp120 concentration was, the stronger the inhibitory effect exerted.Protein kinase A and C inhibitors and the H7 could reverse the inhibition effect.Taken together,this inhibition of LTP by gp120 may contribute to the HAD pathogenesis. |
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| Keywords: | HIV-1 gp120 LTP H7 |
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