Immunization with syngeneic Sendai virus-infected cells induce no MHC-restricted antibodies but antibodies specific for H-2 class I determinants |
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Authors: | Femia Kievits Walter J. Boerenkamp Pavol Ivanyi |
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Affiliation: | (1) c/o Publication Secretariat, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, P.O. Box 9406, NL-1006 AK Amsterdam, The Netherlands;(2) Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands |
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Abstract: | To find out whether immunoglobulins are able to recognize foreign antigens in the context of syngeneic MHC determinants, an effort was made to trigger the production of MHC-restricted antibodies by syngeneic Sendai virus (SV)-infected cells using the spleen-fragment culture technique. Antibodies were found that mimicked MHC-restricted antibodies by recognizing MHC + SV better than MHC alone. However, the binding was not specific for SV and also occurred on mitogen-stimulated (SV–) or influenza virus-infected cells. We describe the production of H-2 class I-specific lymphocytotoxic antibodies by primary B cells responding to syngeneic SV-infected cells. No viral-specific, H-2-restricted antibodies were found. |
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