Synthesis of all stereoisomers of KRN7000, the CD1d-binding NKT cell ligand |
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| Authors: | Park Jeong-Ju Lee Ji Hyung Ghosh Subhash C Bricard Gabriel Venkataswamy Manjunatha M Porcelli Steven A Chung Sung-Kee |
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| Institution: | aDepartment of Chemistry, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea;bDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx 10461, USA |
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| Abstract: | KRN7000 is an important ligand identified for CD1d protein of APC, and KRN7000/CD1d complex can stimulate NKT cells to release Th1 and Th2 cytokines. In an effort to understand the structure–activity relationships, we have carried out the synthesis of a complete set of the eight KRN7000 stereoisomers, and their biological activities have been examined. |
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| Keywords: | α -GalCer KRN7000 stereoisomers Phytosphingosine NKT cell |
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