Junctophilins: a novel family of junctional membrane complex proteins |
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Authors: | Takeshima H Komazaki S Nishi M Iino M Kangawa K |
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Institution: | Division of Cell Biology, Institute of Life Science, Kurume University, Aikawa-machi, Fukuoka, Japan. takeshim@lsi.kurume-u.ac.jp |
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Abstract: | Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/ SR) are a common feature of all excitable cell types and mediate cross-talk between cell surface and intracellular ion channels. We have identified the junctophilins (JPs), a novel conserved family of proteins that are components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. In mouse, there are at least three JP subtypes: JP-1, -2, and -3. JP-2 is abundantly expressed in the heart, and mutant mice lacking JP-2 exhibited embryonic lethality. Cardiac myocytes from the mutant mice showed deficiency of the junctional membrane complexes and abnormal Ca2+ transients. Our results suggest that JPs are important components of junctional membrane complexes. |
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