Unguisin C, a GABA-containing cyclic peptide from the fungus Emericella unguis |
| |
Authors: | Joan Malmstrm Anne Ryager Uffe Anthoni Per Halfdan Nielsen |
| |
Institution: | Joan Malmstrøm, Anne Ryager, Uffe Anthoni,Per Halfdan Nielsen |
| |
Abstract: | Besides the known unguisins A and B, a new cyclic heptapeptide, unguisin C, containing a GABA-derived moiety in the ring, was isolated from the fungus Emericella unguis. The structure was determined by 1D and 2D NMR techniques. Marfey's method was used to determine the absolute stereochemistry. Precursor-directed biosynthesis of the unguisins was performed by supplementation of the culture medium with amino acids (
-Ala,
-Ser,
-Phe and
-Leu). A related cyclic heptapeptide, unguisin D, was detected by HPLC and characterized by sequence analysis using LC-QITMS. |
| |
Keywords: | Emericella unguis Fungus Cyclic peptides GABA Unguisin C Unguisin D |
本文献已被 ScienceDirect 等数据库收录! |
|