A link between copper and dental caries in human teeth identified by X-ray fluorescence elemental mapping |
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| Authors: | Hugh H Harris Stefan Vogt Harold Eastgate Peter A Lay |
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| Institution: | (1) School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia;(2) School of Chemistry and Physics, The University of Adelaide, Adelaide, SA, 5005, Australia;(3) X-ray Science Division, Argonne National Laboratory, Argonne, IL 60439, USA;(4) Eastmac Pty. Ltd., 8 Cassinia Close, Knoxfield, VIC, 3180, Australia |
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| Abstract: | Quantitative X-ray fluorescence imaging of sections of human teeth revealed an increased concentration of copper and zinc
in carious regions of dentine compared with unaffected portions of the tooth. Higher-resolution images provided strong evidence
that the copper was transported and localized mainly in the dentinal tubules. While similar levels of zinc were found in these
areas and concentrated in the tubules, zinc was also more evident in the hydroxyapatite, and the increase in zinc levels compared
with the levels in background (normal) areas was less than that for copper. These results suggest a role for copper and zinc
in the formation and progression of dental caries and present a potential point of intervention for treatment.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
Dedicated to the memory of the late Harold Eastgate. |
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| Keywords: | Dental caries Copper X-ray fluorescence imaging Human teeth |
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