Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

Authors:	Cabreiro Filipe Ackerman Daniel Doonan Ryan Araiz Caroline Back Patricia Papp Diana Braeckman Bart P Gems David

Affiliation:	^a Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK ^b Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, Ghent, Belgium ^c Department of Medical Chemistry, Semmelweis University, 1094 Budapest, Hungary

Abstract:

Keywords:	HNE 4-hydroxynonenal AMPK AMP-dependent kinase CML carboxymethyllysine co-OE co-overexpression HSF-1 heat shock factor-1 IIS insulin/IGF-1 signaling NAC N-acetylcysteine OE overexpression ROS reactive oxygen species RNAi RNA-mediated interference O₂^&bull &minus superoxide anion SOD superoxide dismutase
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