Beta-globin gene haplotypes in Polynesians are predominantly southern Chinese in type |
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| Authors: | R J Trent V Ferguson M S Hertzberg J Rutherford K N Mickleson |
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| Institution: | Molecular Biology Laboratory, University of Sydney, NSW, Australia. |
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| Abstract: | beta-Globin gene haplotypes obtained in Polynesian Samoans were similar to those described in Southern Chinese. An atypical HindIII restriction fragment length polymorphism detected with pRK29, a 3' beta-globin gene probe, was present at a gene frequency of 7% in Samoans. Haplotype patterns suggest that this polymorphism may have arisen by 1 or 2 mutational events. DNA haplotypes derived from the beta-globin gene cluster confirm nuclear and mitochondrial DNA data that Polynesian precursor populations were East Asian in origin. |
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