A probabilistic classifier for olfactory receptor pseudogenes |
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Authors: | Idan Menashe Ronny Aloni and Doron Lancet |
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Institution: | (1) Department of Molecular Genetics and the Crown Human Genome Center, The Weizmann Institute of Science, Rehovot 76100, Israel |
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Abstract: | Background Olfactory receptors (ORs), the largest mammalian gene superfamily (900–1400 genes), has >50% pseudogenes in humans. While
most of these inactive genes are identified via coding frame (nonsense) disruptions, seemingly intact genes may also be inactive
due to other deleterious (missense) mutations. An ultimate assessment of the actual size of the functional human OR repertoire
thus requires an accurate distinction between genes and pseudogenes. |
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Keywords: | |
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