Long-Lasting Enhancement of Corticostriatal Transmission by Taurine: Role of Dopamine and Acetylcholine |
| |
| Authors: | A N Chepkova O A Sergeeva H L Haas |
| |
| Institution: | (1) Department of Neurophysiology, Heinrich-Heine-Universität, Düsseldorf, Germany;(2) Present address: Brain Research Institute, Russian Academy of Medical Sciences, Moscow, Russia;(3) Heinrich-Heine-Universität, Physiology II, POB 101007, D-40001 Düsseldorf, Germany |
| |
| Abstract: | 1. Taurine applied to mouse brain slices evokes a long-lasting enhancement (LLE) of corticostriatal synaptic transmission, LLETAU.2. The occurrence of LLETAU was significantly decreased in the presence of the specific antagonists at either D1 (SCH23390) or D2 (raclopride) dopamine (DA) receptors.3. LLETAU was prevented by scopolamine, a muscarinic antagonist, and significantly suppressed by the nicotinic antagonist mecamylamine.4. Thus, dopaminergic and cholinergic mechanisms, in concert with the taurine transporter and glycine receptors, contribute critically to the induction of corticostriatal LLETAU. |
| |
| Keywords: | plasticity striatum dopamine acetylcholine |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
