Leukotriene A: stereochemistry and enzymatic conversion to leukotriene B |
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| Authors: | Olof Rådmark Curt Malmsten Bengt Samuelsson David A Clark Giichi Goto Anthony Marfat EJ Corey |
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| Institution: | Department of Chemistry, Karolinska Institutet S-104 01 Stockholm, Sweden;Department of Chemistry, Harvard University Cambridge, Mass., USA |
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| Abstract: | Leukotriene A was assigned the structure 5(S)--5,6-oxido-7,9--eicosatetraenoic acid by the enzymatic conversion of a synthetic product of known stereochemistry into the naturally occurring isomer of 5(S),12(R)-dihydroxy-6,8,10,14-eicosatetraenoic acid in human polymorphonuclear leukocytes. |
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| Keywords: | benzo[a]pyrene PMSF phenylmethane-sulfonylfluoride |
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