| 低氧诱导因子-1α基因多态性与肿瘤易感性 |
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| 引用本文： | 张小爱,周钢桥,贺福初.低氧诱导因子-1α基因多态性与肿瘤易感性[J].生物技术通讯,2008,19(5):721-723. |
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| 作者姓名： | 张小爱 周钢桥 贺福初 |
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| 作者单位： | 军事医学科学院,放射与辐射医学研究所,北京蛋白质组研究中心,蛋白质组学国家重点实验室.北京,102206 |
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| 基金项目： | 国家高技术研究发展计划(863计划)，国家自然科学基金，国家重点基础研究发展计划(973计划)，北京市科技新星人才基金 |
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| 摘 要： | 低氧诱导因子-1（HIF-1）是参与调节机体氧平衡的重要转录因子,HIF-1α是其主要的氧调节亚基和功能亚基,体内HIF-1α的水平直接影响着肿瘤的易感性。简要介绍了HIF-1α的生物学功能,并对近年来HIF-1α基因多态性与肿瘤易感性的研究进展进行了回顾。
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| 关 键 词： | 低氧诱导分子-1α 基因多态性 遗传易感性 肿瘤 |
Polymorphisms of Hypoxia Inducible Factor-1α Gene and Susceptibility to Cancers |
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| ZHANG Xiao-Ai,HE Fu-Chu,ZHOU Gang-Qiao.Polymorphisms of Hypoxia Inducible Factor-1α Gene and Susceptibility to Cancers[J].Letters in Biotechnology,2008,19(5):721-723. |
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| Authors: | ZHANG Xiao-Ai HE Fu-Chu ZHOU Gang-Qiao |
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| Institution: | ZHANG Xiao-Ai, HE Fu-Chu, ZHOU Gang-Qiao (State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China) |
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| Abstract: | Hypoxia inducible factor-1 （HIF-1） plays an important role in oxygen homeostasis of the organism. HIF-1 composed of two subunits, HIF-1α and HIF-1β, and among which the HIF-1α is the major regulator of the HIF-1. The levels of HIF-1α produced in vivo influence susceptibility to and severity of cancers, in this review, the biological role of HIF-1α was discussed, and the recent advances of the HIF-1α polymorphisms as well as its associations with the susceptibility to cancers were summarized. |
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| Keywords: | hypoxia inducible factor-1α polymorphism susceptibility cancers |
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