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Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules
Authors:Sebastian Markmiller  Sahar Soltanieh  Kari L Server  Raymond Mak  Wenhao Jin  Mark Y Fang  En-Ching Luo  Florian Krach  Dejun Yang  Anindya Sen  Amit Fulzele  Jacob M Wozniak  David J Gonzalez  Mark W Kankel  Fen-Biao Gao  Eric J Bennett  Eric Lécuyer  Gene W Yeo
Institution:1. Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA;2. Stem Cell Program, University of California, San Diego, La Jolla, CA 92093, USA;3. Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92039, USA;4. Institut de Recherches Cliniques de Montréal, Montréal, QC H2W 1R7, Canada;5. Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA;6. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore;7. Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01605, USA;8. Neuromuscular & Movement Disorders, Biogen, Cambridge, MA 02142, USA;9. Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA;10. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA;11. Département de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, QC H3C 3J7, Canada;12. Division of Experimental Medicine, McGill University, Montréal, QC H3A 1A3, Canada
Abstract:
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  • Keywords:neurodegeneration  amyotrophic lateral sclerosis  RNA-binding proteins  ribonucleoprotein  granules  heat shock  stress  motor neuron disease  phase separation
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