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Urea derivative catalyzed enantioselective aldol reaction of isatins with ketones |
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| Authors: | Li Ming Wang Mei Jun Zhao Zhe Chen Hong Wen Mu Ying Jin |
| Institution: | Department of Pharmacy, Jilin Medical University, Jilin, China |
| Abstract: | Urea derivative has been used to catalyze the asymmetric aldol reaction of isatins with ketones. The resulting 3‐alkyl‐3‐hydroxy‐indolin‐2‐ones products were obtained in good yields (70%‐94%) with high enantioselectivities (up to 87%ee). |
| Keywords: | 3‐alkyl‐3‐hydroxy‐indolin‐2‐ones enantioselective aldol reaction isatins urea derivative |