Atropisomerism in Rilpivirine hydrochloride: Spectroscopic characterization of Rilpivirine and related impurities |
| |
| Authors: | Senthilkumar Natarajan Hiriyanna Salmara Ganeshbhat Sujeet Shrivastava Srimurugan Sankareswaran Pramod Kumar |
| |
| Institution: | 1. Analytical Research Department, API R&D Centre, Microlabs Ltd., Bangalore, Karnataka, India;2. Chemical Research Department, API R&D Centre, Microlabs Ltd., Bangalore, Karnataka, India |
| |
| Abstract: | Nuclear magnetic resonance (NMR) technique has been used to find the property of atropisomerism in Rilpivirine hydrochloride by variable temperature analysis and various 2D techniques. Both the Rilpivirine hydrochloride (E‐isomer) and Impurity‐A (Z‐isomer) isomers have been differentiated and confirmed by NMR and ultraviolet techniques. Preparative high‐performance liquid chromatography isolation for Impurity‐A is followed by spectroscopic (NMR, mass spectra, and infrared) investigation that provides a perfect solution for determination of the structure of Rilpivirine and related impurities. |
| |
| Keywords: | atropisomerism geometric isomers nuclear magnetic resonance Rilpivirine hydrochloride |
|
|
