Constrained flexibility in PNA: DNA binding studies with bridged aminopropylglycyl PNA |
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| Authors: | Lonkar P S Kumar V A Ganesh K N |
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| Institution: | Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411 008, India. |
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| Abstract: | Introduction of methylene bridges in aegPNA and apgPNA molecules give rise to cyclic five and six membered ring structures. Synthesis of a new six membered cyclic PNA monomer, aminopipecolyl PNA (pipPNA) is reported. Incorporation of pipPNA into PNA oligomers and comparative binding with target DNA sequences is studied. |
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